The goal of the FAITH project (Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment) is to remotely identify and predict depressive symptoms in cancer survivors using a federated machine learning approach that prioritizes privacy. The target audience includes healthcare professionals, researchers, technology developers and cancer survivors. The FAITH project leverages the following key areas of digital health: wearable technology, cloud-based technology, and predictive Artificial Intelligence (AI). As cancer survival rates rise due to improved screening and treatment, many survivors face long-term physical and psychological challenges, such as depression, anxiety, and cognitive impairment. Depression is more common in cancer survivors than in the general population, if untreated, can significantly reduce quality of life and increase healthcare needs. Overlapping symptoms like fatigue and sleep disturbances make it harder to differentiate depression from cancer-related effects.
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ARTIFICIAL INTELLIGENCE USED IN DEPRESSION DETECTION IN CANCER SURVIVORS
Publication type: Article Summary
Original title: A prospective observational study for a Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment (FAITH): study protocol
Article publication date: December 2022
Source: BMC Psychiatry
Authors: Raquel Lemos, Sofia Areias-Marques, Pedro Ferreira, Philip O’Brien, María Eugenia Beltrán-Jaunsarás, Gabriela Ribeiro, Miguel Martín, María del Monte-Millán, Sara López-Tarruella, Tatiana Massarrah, Fernando Luís-Ferreira, Giuseppe Frau, Stefanos Venios, Gary McManus & Albino J. Oliveira-Maia
What is the goal, target audience, and areas of digital health it addresses?
The goal of the FAITH project (Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment) is to remotely identify and predict depressive symptoms in cancer survivors using a federated machine learning approach that prioritizes privacy. The target audience includes healthcare professionals, researchers, technology developers and cancer survivors. The FAITH project leverages the following key areas of digital health: wearable technology, cloud-based technology, and predictive Artificial Intelligence (AI).
What is the context?
As cancer survival rates rise due to improved screening and treatment, many survivors face long-term physical and psychological challenges, such as depression, anxiety, and cognitive impairment. Depression is more common in cancer survivors than in the general population, if untreated, can significantly reduce quality of life and increase healthcare needs. Overlapping symptoms like fatigue and sleep disturbances make it harder to differentiate depression from cancer-related effects.
Federated machine learning is a decentralized method that trains AI models across multiple devices without sharing personal data. Each device processes its own data and sends only updates to a central server, ensuring privacy. The server combines these updates to improve the overall model, then sends the refined version back to each device. This continuous process makes the predictions more accurate through collective learning, and also allows each device’s AI model to remain personalized, adapting to the user’s specific data.
What are the current approaches?
Traditional approaches to identifying depression in cancer survivors typically focus on the early years post-diagnosis, when patients are still in regular follow-up care. Current methods primarily rely on self-rated questionnaires, occasional clinical assessments, and symptom-based interviews. While these self-reporting tools are quick, easy, and cost-effective, they tend to miss key somatic symptoms like fatigue, appetite changes, and sleep disturbances. Additionally, these tools alone cannot provide a clinical diagnosis, which requires structured or semi-structured interviews. The infrequent follow-ups and reliance on subjective data often result in undetected cases of depression, especially after cancer treatment ends.
What does the FAITH project consist of? How is the impact of this FAITH project assessed?
The FAITH project consists of a privacy-focused AI system designed to provide real-time insights into patients’ mental health through the analysis of 4 key depression markers: Activity, Sleep, Nutrition, and Voice, using this data to predict the risk of depression. The FAITH app integrates both passive data collection (automatic tracking of sleep and physical activity via smartbands and smartphones) and proactive data collection (self-reporting of nutrition habits through validated questionnaires and voice recordings).
The FAITH project leverages federated machine learning, enabling AI models to be trained directly on users’ devices using local data from four key markers to predict depression risk. Statistical analyses, such as neural network modeling, further improve the accuracy of these predictions while incorporating bias reduction strategies. The platform operates on the Amazon Web Services (AWS) cloud, providing scalable storage and robust cybersecurity. This decentralized approach safeguards sensitive information, while data pseudonymization (replacing personal identifiers with coded identifiers) and strict compliance with General Data Protection Regulation (GDPR) standards ensure a high level of privacy and adherence to European data protection laws.
The impact of the FAITH project is assessed through a longitudinal prospective study involving 300 breast or lung cancer survivors, recruited 1 to 5 years post-treatment. Participants are continuously monitored for sleep and physical activity. Each month, they self-report anxiety and depression using the Hospital Anxiety and Depression Scale (HADS), assess their quality of life with the EORTC questionnaires, and complete nutrition assessments. They also do monthly voice recordings, as speech patterns can offer insights into emotional well-being. Every 3 months, participants fill the applicable sleep and eating behavior questionnaires, and a clinician conducts a phone assessment for depressive symptoms using the Hamilton Depression Rating Scale (Ham-D).
What are the predictable results? What is the future of FAITH project?
In the FAITH project, the user-friendly design and streamlined flow encourage consistent participation without overwhelming users. This regular engagement ensures high-quality data, enabling the algorithms to make accurate real-time predictions and trigger immediate alerts for healthcare professionals when depression markers exceed defined thresholds. The expected results include earlier detection of depressive episodes and timely interventions that improve patients’ quality of life and ease the burden on healthcare systems.
The future of the FAITH project goes beyond cancer care, with the potential to apply this privacy-focused digital health tool to other chronic diseases and mental health conditions. Its long-term success relies on refining the AI model, completing clinical trials, and continuously improving usability and feasibility based on feedback. Future updates will help healthcare professionals better understand how the AI reaches its conclusions, leading to more informed decision-making and more personalized interventions.
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Home / Publications / Publication

ARTIFICIAL INTELLIGENCE USED IN DEPRESSION DETECTION IN CANCER SURVIVORS
Publication type: Article Summary
Original title: A prospective observational study for a Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment (FAITH): study protocol
Article publication date: December 2022
Source: BMC Psychiatry
Authors: Raquel Lemos, Sofia Areias-Marques, Pedro Ferreira, Philip O’Brien, María Eugenia Beltrán-Jaunsarás, Gabriela Ribeiro, Miguel Martín, María del Monte-Millán, Sara López-Tarruella, Tatiana Massarrah, Fernando Luís-Ferreira, Giuseppe Frau, Stefanos Venios, Gary McManus & Albino J. Oliveira-Maia
What is the goal, target audience, and areas of digital health it addresses?
The goal of the FAITH project (Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment) is to remotely identify and predict depressive symptoms in cancer survivors using a federated machine learning approach that prioritizes privacy. The target audience includes healthcare professionals, researchers, technology developers and cancer survivors. The FAITH project leverages the following key areas of digital health: wearable technology, cloud-based technology, and predictive Artificial Intelligence (AI).
What is the context?
As cancer survival rates rise due to improved screening and treatment, many survivors face long-term physical and psychological challenges, such as depression, anxiety, and cognitive impairment. Depression is more common in cancer survivors than in the general population, if untreated, can significantly reduce quality of life and increase healthcare needs. Overlapping symptoms like fatigue and sleep disturbances make it harder to differentiate depression from cancer-related effects.
Federated machine learning is a decentralized method that trains AI models across multiple devices without sharing personal data. Each device processes its own data and sends only updates to a central server, ensuring privacy. The server combines these updates to improve the overall model, then sends the refined version back to each device. This continuous process makes the predictions more accurate through collective learning, and also allows each device’s AI model to remain personalized, adapting to the user’s specific data.
What are the current approaches?
Traditional approaches to identifying depression in cancer survivors typically focus on the early years post-diagnosis, when patients are still in regular follow-up care. Current methods primarily rely on self-rated questionnaires, occasional clinical assessments, and symptom-based interviews. While these self-reporting tools are quick, easy, and cost-effective, they tend to miss key somatic symptoms like fatigue, appetite changes, and sleep disturbances. Additionally, these tools alone cannot provide a clinical diagnosis, which requires structured or semi-structured interviews. The infrequent follow-ups and reliance on subjective data often result in undetected cases of depression, especially after cancer treatment ends.
What does the FAITH project consist of? How is the impact of this FAITH project assessed?
The FAITH project consists of a privacy-focused AI system designed to provide real-time insights into patients’ mental health through the analysis of 4 key depression markers: Activity, Sleep, Nutrition, and Voice, using this data to predict the risk of depression. The FAITH app integrates both passive data collection (automatic tracking of sleep and physical activity via smartbands and smartphones) and proactive data collection (self-reporting of nutrition habits through validated questionnaires and voice recordings).
The FAITH project leverages federated machine learning, enabling AI models to be trained directly on users’ devices using local data from four key markers to predict depression risk. Statistical analyses, such as neural network modeling, further improve the accuracy of these predictions while incorporating bias reduction strategies. The platform operates on the Amazon Web Services (AWS) cloud, providing scalable storage and robust cybersecurity. This decentralized approach safeguards sensitive information, while data pseudonymization (replacing personal identifiers with coded identifiers) and strict compliance with General Data Protection Regulation (GDPR) standards ensure a high level of privacy and adherence to European data protection laws.
The impact of the FAITH project is assessed through a longitudinal prospective study involving 300 breast or lung cancer survivors, recruited 1 to 5 years post-treatment. Participants are continuously monitored for sleep and physical activity. Each month, they self-report anxiety and depression using the Hospital Anxiety and Depression Scale (HADS), assess their quality of life with the EORTC questionnaires, and complete nutrition assessments. They also do monthly voice recordings, as speech patterns can offer insights into emotional well-being. Every 3 months, participants fill the applicable sleep and eating behavior questionnaires, and a clinician conducts a phone assessment for depressive symptoms using the Hamilton Depression Rating Scale (Ham-D).
What are the predictable results? What is the future of FAITH project?
In the FAITH project, the user-friendly design and streamlined flow encourage consistent participation without overwhelming users. This regular engagement ensures high-quality data, enabling the algorithms to make accurate real-time predictions and trigger immediate alerts for healthcare professionals when depression markers exceed defined thresholds. The expected results include earlier detection of depressive episodes and timely interventions that improve patients’ quality of life and ease the burden on healthcare systems.
The future of the FAITH project goes beyond cancer care, with the potential to apply this privacy-focused digital health tool to other chronic diseases and mental health conditions. Its long-term success relies on refining the AI model, completing clinical trials, and continuously improving usability and feasibility based on feedback. Future updates will help healthcare professionals better understand how the AI reaches its conclusions, leading to more informed decision-making and more personalized interventions.
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